Cell division is essential to the propagation of life. During cell division, mitotic spindles segregate duplicated chromosomes with high fidelity. Spindle structure depends on the proper polar ...

Zachary Gergely, Michele Jones, Bojun Zhou, Cai Cash, J. Richard McIntosh, and Meredith D. Betterton (2023). Distinct regions of the kinesin-5 C-terminal tail are essential for mitotic spindle midzone ...

Many millions of times per day, football-shaped structures called mitotic spindles form within the body's cells as they prepare to divide. The process is routine but mysterious, as the micro-mechanics ...

When cells divide, microtubules – a dynamic network of protein filaments – form a mitotic spindle that draws the chromosomes apart and arranges them into two daughter cells. Here, plants and animals ...

This is a preview. Log in through your library . Abstract The mitotic spindle of L strain fibroblasts, fixed with glutaraldehyde followed by osmium tetroxide, contains many 150- to 180-A tubules. They ...

RanGAP1 was the first documented substrate for conjugation with the ubiquitin-like protein SUMO-1. However, the functional significance of this conjugation has not been fully clarified. We sought to ...

Mitotic spindles are dynamic, self-organizing, intracellular structures that are essential for cell division. Spindles are composed of proteins, cytoskeletal elements and microtubules, which are a key ...

Mitosis is the process by which the genetic information encoded on chromosomes is equally distributed to two daughter cells, a fundamental feature of all life on earth. Scientists now examine how ...

Glioblastoma (GBM) is the most common and aggressive brain tumor in adults. Yet, there are currently no highly effective therapies to treat patients with GBM and ~90% patients die within 2 years of ...

A normally operating mitotic spindle in C-elegan with chromosomes in red amid pipe-like microtubules in green and densely packed microtubules in yellow. Centrioles, unseen, are inside the two yellow ...